INTRODUCTION: In the last five years, our research group generated data on the expression of different proteins in colorectal adenocarcinoma. Many of these data have not yet been published. Therefore, this project intend was the elaboration of a scientific article on the BCL2L1 protein – an anti-apoptotic protein correlated with the development and progression of different types of tumors. OBJECTIVE: To evaluate the expression of the BCL2L1 protein in colorectal adenocarcinoma and its relationship with the histopathological properties of the tumors and the clinicopathological characteristics of the patients, in addition to the correlation of other proteins analyzed in the samples, such as parkin. MATERIAL AND METHODS: For the correct interpretation of the data, an extensive reading was carried out on the laboratory techniques used by the group to define the expression of the protein, as well as the statistical tests performed. Thus, all BCL2L1 expression results and statistical analysis were reviewed and interpreted together with the literature. Finally, the scientific article was written. RESULTS: The main results reported in the article, were: the higher expression of the protein in control samples, associated to the fact that they were collected from tumor borders, which may already have genetic alterations; the correlation between BCL2L1 expression and the presence of compromised lymph nodes; the correlation between BCL2L1 expression and patient survival rates which still needs to be understood, despite similar data having already been presented for other cancer types; the positive correlation between the expression of parkin and that of BCL2L1, which is possibly detected in the samples due to some mutation in the PARK2 gene. FINAL CONCLUSION: The version presented in this report is the first of this article, which will still go through stages of review before being submitted for publication.
